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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 1,633–1,644 of 2,098 articles

PLOS

Mechanisms of cellular senescence combined with molecular docking strategies: A biomarker study of potential therapeutic targets for allergic rhinitis

Objective: Bioinformatics and molecular docking methods were used to screen potential biomarkers of cellular senescence in allergic rhinitis (Allergic rhinitis AR), which provided a theoretical basis for revealing the mechanism of AR and exploring new therapeutic approaches. Methods: Four AR-related gene chips (GSE19187, GSE43523, GSE44037, and GSE51392) were downloaded from the gene expression database (GEO) for data pooling. Screening differential genes (DEGs) were taken to intersect with cell...

Articles
Qingyong Chen, Han Zhang, Yue Wu, Jixin Liu, Dongqing Wang, Dezhong Sun, Zhipeng Chen, Liqiang Lin, Huaiqing Lv, Qiang Shao•
PLOS

LIMPACAT: Multi-omics attention transformer for immune prediction in liver cancer using whole-slide imaging

Characterizing the tumor immune microenvironment from histopathological images offers opportunities for ex vivo immune profiling and prognostic assessment. However, the TCGA-LIHC dataset lacks direct immune cell composition data. Therefore, this study aims to introduce Liver Immune Microenvironment Prediction and Classification Attention Transformer (LIMPACAT), a deep learning framework that leverages whole-slide images (WSIs) to predict immune cell levels relevant to hepatocellular carcinoma (H...

Articles
Yen-Jung Chiu•
PubMed

The Risk of Obstructive Sleep Apnea Among Patients With Major Depressive Disorder and Generalized Anxiety Disorder in Saudi Arabia: A Cross-Sectional Study.

Introduction Obstructive sleep apnea (OSA) is a common sleeping disorder characterized by recurring episodes of upper airway collapse during sleep. The relationship between OSA and psychiatric disorders, particularly depression and anxiety, has gained significant attention due to their frequent co-occurrence and bidirectional relationship. In this study, we assessed the risk of OSA among patients with psychiatric disorders and evaluated associated factors such as sleep quality and daytime sleep...

Articles
Alswat AM, Qanash S, Aldahlawi A, Alhaddad A, Albishry A, Qari SA, Jarwan AS, Alkaki AA, Mufti HN, Alaseeri B, Alwafi H, Naser AY•
PubMed

Genome-wide association study of event-free survival in follicular lymphoma patients treated with front-line immunochemotherapy.

Genome-wide association studies (GWAS) have identified germline genetic variants for follicular lymphoma (FL) susceptibility. We conducted a GWAS of prognosis in FL patients to identify genetic predictors of event-free survival (EFS) as well as failure within the first 24 months after treatment initiation (EFS24) using patients treated with rituximab-based immunochemotherapy from three clinical trials and one prospective observational study (N = 1054). Statistical approaches consisted of a poole...

Articles
Ghesquières H, Drouet Y, Slager SL, Morschhauser F, Julia E, Galimberti S, Robinson D, Larson MC, Testard Q, Tesson B, Deleuze JF, Boland A, Thomas E, Lasset C, Novak AJ, Xerri L, Luminari S, Verney A, Laurent C, Rimsza LM, Habermann TM, Federico M, Link BK, Salles G, Cerhan JR•
PubMed

Breaking the cycle: successful long-term remission of chronic erythema multiforme with rituximab therapy.

Abstract Erythema multiforme (EM) is an immune-mediated condition marked by recurrent targetoid lesions, occasionally involving mucous membranes. Chronic or treatment-resistant cases can be difficult to manage, with limited options when standard therapies fail. We report a 37-year-old man with long-standing, refractory EM who experienced frequent flares despite trials of corticosteroids, antivirals, dapsone, methotrexate, hydroxychloroquine, ciclosporin, thalidomide and intravenous immunoglobul...

Articles
Ghani H, Haq Z, Tan I, Reginato A, Qureshi AA•
PubMed

Trends in systemic lupus erythematosus incidence and prevalence among Korean women of childbearing age: a nationwide study 2011~2020.

Objective Despite advances in systemic lupus erythematosus (SLE) care, the disease remains a significant burden for women of childbearing age. This study assessed trends in SLE incidence and prevalence among women of childbearing age from 2011 to 2020, comparing the periods 2011~2015 and 2016~2020. Methods Women aged 20~49 with SLE were identified from National Health Insurance Service-National Health Information Database (2009~2020). SLE was defined by ICD-10 (International Classification of...

Articles
Chung MK, Park JS, Lim H, Baek IW, Park PG, Lee CH, Lee J•
PubMed

Hyperlipidemia exacerbates frozen shoulder fibrosis by activating the TGF-β/Smad2/3 signaling pathway via the TBX5-TNC-Itgα2 axis.

Summary Hyperlipidemia is strongly implicated in frozen shoulder, but the molecular mechanisms linking this systemic metabolic disorder to localized joint fibrosis remain unknown. To elucidate this, we established a hyperlipidemic rat model and employed transcriptomics, along with comprehensive molecular validation assays, in human synovial fibroblasts. We discovered that oxidized low-density lipoprotein initiates the fibrotic cascade by upregulating the transcription factor TBX5. TBX5 then tra...

Articles
Jiang F, Zhang Y, Ma J, Yu T, Shen Y•
PubMed

Intracellular Oxidant Levels Are Crucial for Cell Survival and JAK/STAT Signaling in Classical Hodgkin's Lymphoma.

Although oxidants are known to be deleterious for cellular homeostasis by oxidizing macromolecules like DNA or proteins, they are also involved in signaling processes essential for cellular proliferation and survival. Here, we investigated the role of superoxide anion (O2−) and hydrogen peroxide (H2O2) homeostasis for the proliferation and survival of classical Hodgkin’s lymphoma (cHL) cell lines. Inhibition of NADPH oxidases (NOX) using apocynin (Apo) and diphenylene iodonium (DPI), or treatmen...

Articles
Wildfeuer J, Dheenadayalan RP, Hartung S, Zahn M, Albrecht TP, Cao Z, Ushmorov A, Möller P, Gaisa NT, Marienfeld R•
PubMed

No significant short-term advantages of corticosteroids-augmented intra-articular injections of hyaluronic acid for knee osteoarthritis : A meta-analysis.

Introduction The present meta-analysis investigated whether augmenting hyaluronic acid (HA) with corticosteroids (CCs) is more effective than HA in isolation in patients with knee osteoarthritis (OA). The outcomes of interest were the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores. Methods This study was conducted according to the 2020 PRISMA statement. In September 2025 the following databases were accessed: PubMed, Web of Science, Google Scholar and Embase. Al...

Articles
Migliorini F, Giorgino R, Oliva F, Pipino G, Memminger MK, Maffulli N•
PubMed

Cosmeceuticals in acne vulgaris: from mechanism of action to clinical application.

Abstract The use of cosmeceuticals in acne vulgaris is becoming increasingly prevalent with many over-the-counter formulations becoming part of patients’ routine skincare. Cosmeceuticals are often used successfully as an adjunctive therapy to reduce the side effects of traditional prescriptions and improve compliance. This is a review to support the use of cosmeceuticals in acne, including retinol, retinaldehyde, benzoyl peroxide (BPO), azelaic acid, beta hydroxy acids, alpha hydroxy acids, nia...

Articles
Searle TN, Al-Niaimi F, Ali FR•
PubMed

The utility of biopsy in pyoderma gangrenosum: a retrospective cohort study.

Abstract Background Pyoderma gangrenosum (PG) is a rare skin condition characterized by chronic, painful ulcerations. It is considered a diagnosis of exclusion, often resulting in diagnostic delay. Histological results in PG, even when biopsied despite a risk of pathergy, are nonspecific. Objectives To examine retrospectively the utility of biopsies in the diagnosis of 58 patients treated for PG. Methods Medical records were reviewed to compare biopsy results versus the efficacy of diagnos...

Articles
Moore AM, Karch JL, Bradley KE, Stevanovic M, Salem I, Parker DJ, Simmons BJ•
PubMed

Spine-limited Rosai-Dorfman disease in a patient with ankylosing spondylitis - A rare mimicker of spinal tumors.

Background: Rosai–Dorfman disease (RDD) is an uncommon histiocytic proliferative disorder that typically involves the lymph nodes but can also present with extranodal involvement. Central nervous system involvement is rare, and the spine-restricted RDD is an extremely rare variant that poses significant diagnostic challenges, often resulting in delays in diagnosis and management. Case Description: We report a case of a 32-year-old gentleman with a history of back pain for 1-year, initially be...

Articles
Masroor M, Javed Z, Gilani A, Shamim SM•