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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 1,777–1,788 of 2,098 articles

PubMed

Real-world outcomes of ustekinumab, vedolizumab, and tumor necrosis factor inhibitors in very-early-onset inflammatory bowel disease: a multi-center cohort study.

Background Very-early-onset inflammatory bowel disease (VEO-IBD), representing cases diagnosed before age 6 years, is increasing in prevalence. Although VEO-IBD often presents as severe, treatment-resistant disease requiring biologic agents, studies showing the effectiveness of biologics, such as ustekinumab (UST) and vedolizumab (VDZ), remain limited. Methods We retrospectively analyzed patients with VEO-IBD treated for at least a year from 13 institutions in Japan, evaluating clinical cours...

Articles
Nambu R, Iwama I, Takeuchi I, Hagiwara SI, Etani Y, Kaji E, Yoden A, Kakuta F, Hoshi Y, Tsumura N, Mizuochi T, Kumagai H, Yokoyama K, Nishizawa T, Usami M, Takaki Y, Ebana R, Kurasawa S, Fujikawa H, Ishige T, Kudo T, Yoshida MM, Shimizu H, Arai K•
PubMed

Acute Exacerbation of Chronic Periapical Pathology in a Dentist: An Autobiographical Case Report.

Acute exacerbations of chronic periapical pathology require prompt surgical or endodontic intervention, supported by pharmacotherapy. The role of analgesic selection, escalation, and rotation in acute dental pain remains underexplored. A 39-year-old male dentist with a 27-year history of trauma to the lower left central incisor presented with acute pain of three hours’ duration. The tooth was non-vital with a stable periapical granuloma documented for over 15 years. Self-medication began with pa...

Articles
Sekar R, Maheswaran T, Chittrarasu M, Vijayparthiban S, Suresh R•
PubMed

Chiropractic spinal manipulative therapy versus physical therapist-led exercise and the risk of cauda equina syndrome in adults with lumbar disc herniation, stenosis, or radiculopathy.

Abstract Background Cauda equina syndrome is a surgical emergency often caused by lumbar disc herniation. Spinal manipulative therapy is commonly used for lumbar spine disorders, but case reports have raised concerns it may precipitate cauda equina syndrome. One cohort study suggested no increased risk, although it did not focus on patients with lumbar spine disorders pertinent to cauda equina syndrome, such as disc herniation, stenosis, or radiculopathy/sciatica. Objective To address this e...

Articles
Trager RJ, Baumann AN, Perfecto RT, Goertz CM•
PubMed

Classification of pulmonary diseases using machine learning and deep learning models on GLI-2012 standardized spirometry features.

Background Artificial intelligence applications play an increasingly important role in medical diagnosis processes, nowadays. Spirometry, which is widely used among lung function tests, is an important method in the early diagnosis of pulmonary diseases and monitoring. In this study, the performances of different machine learning and deep learning algorithms in classifying pulmonary diseases were examined using a set of Global Lung Initiative 2012 standardized spirometry features. Methods The...

Articles
Koca YB•
PubMed

Lyme disease as a rare trigger for autoimmune hemolytic anemia.

Introduction Lyme disease, caused by Borrelia burgdorferi, is a zoonotic infection affecting the skin, nervous system, joints, and heart. Diagnosis relies on clinical history, symptoms, and a two steps serologic test confirmed by Western Blot. Although it frequently affects other systems, data on the haematological involvement spectrum of Lyme disease appears to be limited to case reports, and there are few studies that clearly demonstrate its relationship with haemolytic anaemia. This case hig...

Articles
Kulu UA, Kalkan IA, Keskin H•
PubMed

Liver cancer segmentator: Metadata-guided confidence scoring for reliable segmentation of colorectal liver metastases in CT.

Background and Objective: This study introduces the liver cancer segmentator (LCS), a deep learning model designed for automatic and robust segmentation of liver parenchyma and tumors in abdominal contrast-enhanced computed tomography images from patients with colorectal liver metastases. The primary aim was to enhance confidence scoring for more reliable clinical segmentation assessment. Methods: In this retrospective study, 446 abdominal contrast-enhanced computed tomography examinations we...

Articles
Hamghalam M, Peoples JJ, Kobayashi KSM, Park G, Kwak E, Bunker EC, Gangai N, Gonen M, Chun YS, Kang HC, Do RKG, Simpson AL•
PubMed

The Efficacy and Safety of Nutritional Supplements for Cancer Supportive Care: An Umbrella Review and Hierarchical Evidence Synthesis.

Cancer survivors experience a range of side effects during and after treatment. There is a need for a rigorous synthesis of the most recent and best available evidence on the role of nutritional supplements for supportive care in cancer, to inform shared decision-making. We searched 5 databases for umbrella reviews, meta-analyses and systematic reviews on nutritional supplements for supportive cancer care, excluding studies on pain, anxiety and depression, which are covered in recent guidelines....

Articles
Benna-Doyle S, Grant S, Maunder A, Liu J, Ibrahim M, Cave A, Pandey C, Tang M, Koh ES, Delaney G, Bhuyan DJ, Choi V, Kwon K, Gonzalez M, Graham S, Malalasekera A, Ee C•
CDC

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Articles
PLOS

Evaluation of culture- and PCR-based methods for detecting Burkholderia pseudomallei in soil samples in Thailand

Background: Burkholderia pseudomallei is an environmental bacterium that causes melioidosis, a life-threatening disease prevalent in tropical regions. Accurate detection of B. pseudomallei in the environment is essential for identifying areas that pose an infection risk. This study aimed to evaluate culture- and real-time polymerase chain reaction (PCR)-based methods for detecting B. pseudomallei directly in soil samples, and to assess its environmental prevalence in relation to antibody levels...

Articles
Didtawa Suttisak, Charlene Mae Salao Cagape, Rathanin Seng, Natnaree Saiprom, Wongwarut Boonyanugomol, Kamolchanok Rukseree, Paul J. Brett, Mary N. Burtnick, Narisara Chantratita•
PLOS

The relationship between Braden Skin Score (BSS) and the risk of acute respiratory distress syndrome in elderly sepsis patients: An analysis based on the MIMIC-IV database

Objective: The Braden Skin Score (BSS) is a validated tool for assessing pressure injury risk. This study aimed to investigate whether BSS can also predict the risk of developing Acute Respiratory Distress Syndrome (ARDS) in elderly sepsis patients in the intensive care unit (ICU). Background: ARDS is a common and serious complication in ICU patients with sepsis, associated with prolonged hospitalization, metabolic disorders, and increased mortality. Elderly sepsis patients are particularly vuln...

Articles
Yingqi Xiao, Yi Cao, Jianwen Guo, Liufang Shu, Jingcheng Xu, Zhiyong Li, Yongchun Li•
PLOS

Targeting of interaction between BB0323-BB0238 informs new paradigms in Lyme disease therapeutics

Borrelia burgdorferi, one of the most prevalent tick-borne pathogens, can cause a complex and multisystem illness called Lyme disease, where there has been an unmet need for novel therapeutic or preventive strategies. We previously identified an essential protein-protein interaction (PPI) event in B. burgdorferi involving two unique proteins, BB0323 and BB0238; herein, we show that this PPI is indispensable for long-term borrelial survival in mammals and explore its potential as a novel target f...

Articles
Sandhya Bista, Kalvis Brangulis, Bibek Bhattachan, Shelby D. Foor, Michael H. Ronzetti, Sankalp Jain, Jenna Miller, Jothy Lachumy Subramanion, Chrysoula Kitsou, Vipin S. Rana, Ganesha Rai, Alexey V. Zakharov, Anton Simeonov, Bolormaa Baljinnyam, Utpal Pal•
PLOS

Uric acid levels mediate the association between four dietary indices and kidney stones in US adults: A cross-sectional study of NHANES 2007–2018

Background: Diet and uric acid are closely linked to the formation of kidney stones. However, the specific dietary indices associated with kidney stone risk and the mediating role of uric acid remain unclear. This study investigates the association between four dietary indices and kidney stone risk while exploring the mediating role of uric acid. Methods: Data were obtained from the National Health and Nutrition Examination Survey (NHANES). Four dietary indices were calculated: the Mediterranean...

Articles
Jinlong Cao, Tianyuan Zhai, Lingyu Guo, Yue Chong, Qi Chen, Qian Wang, Delai Fu, Li Xue, Feng Li•