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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 1,789–1,800 of 2,098 articles

PLOS

Predicting adherence to fully-automated, chatbot-delivered digital cognitive behavioral therapy for insomnia (dCBT-I) using machine learning: A pilot real-world study

Digital cognitive behavioral therapy for insomnia (dCBT-I) is effective in treating insomnia, but adherence remains a major challenge in real-world applications. Machine learning (ML) offers potential in predicting healthcare utilization. This study applied ML techniques to predict adherence to dCBT-I based on participant baseline characteristics. This pilot real-world study included 75 individuals (69% female; 41% aged 35–44 years) with insomnia symptoms (Insomnia Severity Index, ISI ≥ 8) who p...

Articles
Rose Wing Lai So, Kit Ying Chan, Christopher Chi Wai Cheng, Ngan Yin Chan, Shirley Xin Li, Joey Wing Yan Chan, Steven Wai Ho Chau, Yun Kwok Wing, Tim Man Ho Li•
PLOS

A protocol for using rapid qualitative techniques to incorporate multi-level stakeholder feedback in a pragmatic clinical trial of mindfulness for chronic low back pain

Introduction: Engaging community members and context experts is increasingly recognized as key to developing research that is responsive to community needs. Here, we describe a protocol for incorporating stakeholder feedback using rapid qualitative techniques into OPTIMUM (Optimizing Pain Treatment In Medical settings Using Mindfulness), a pragmatic clinical trial comparing a telemedicine-delivered mindfulness-based stress reduction intervention to usual care to address chronic low back pain. Th...

Articles
Isabel J. Roth, Elondra D. Harr, Christine R. Lathren, Jessica L. Barnhill, Ruth D. Rodriguez, Jose E. Baez, Natalia E. Morone•
PLOS

Predictors of depression in asthma patients in an Indian referral hospital

Background: Asthma has been shown to have a significant association with the diagnoses of mental health disorders, including depression; however, information from India is scarce. Objectives: The study aims to estimate the prevalence of depression in asthma patients and identify associated risk factors. Methods: A total of 248 participants aged 18 and above who presented to the pulmonary medicine outpatient clinic of the Christian Medical College, Vellore, Tamil Nadu, India, were recruited. Soci...

Articles
Anushka Kataria, Jefferson Daniel, Barney Isaac, Balamugesh Thangakunam, Jesson Paulson Illimoottil, Reka Karuppusami, Devasahayam J. Christopher•
PLOS

Analysis of common differential gene expression between rheumatoid arthritis and ulcerative colitis

Objective: This study employs bioinformatics analysis with the objective of identifying commonly differentially expressed genes (DEGs) in ulcerative colitis (UC) and rheumatoid arthritis (RA), as well as exploring their underlying molecular mechanisms. By doing so, it aims to provide a theoretical basis for investigating the potential associations between these two diseases and developing novel therapeutic strategies. Materials and methods: We downloaded multiple gene expression datasets for Rhe...

Articles
Peng-fei Han, Wei-rong Cui, Fang-zheng He, Tao Wu, Chang-sheng Liao•
PLOS

Consensus on recommended evaluation tools in multiple sclerosis (CORE-MS): A Delphi study protocol on balance and gait assessment

Background and objectives: Gait and balance impairments are common and disabling in People with Multiple Sclerosis (PwMS), significantly affecting mobility and quality of life. Although several clinical and instrumental tools exist to assess these functions, there is no consensus on the most appropriate measures for detecting changes at the clinical, movement quality, and neural levels. This study aims to establish expert consensus on the most appropriate tools for assessing gait and balance in...

Articles
Rebecca Cardini, Elisa Gervasoni, Marco Germanotta, Irene Giovanna Aprile, Francesca Cecchi, Chiara Pedrini, Massimiliano Gobbo, Joel Pollet, Rosa Pullara, Maria Pia Amato, Guido Pasquini, Filippo Gerli, Davide Cattaneo•
PubMed

Genome-Wide Association Study for Glucocorticoid-Induced Ocular Hypertension.

Purpose: To identify genetic variants associated with glucocorticoid (GC)-induced intraocular pressure (IOP) change using genome-wide association study (GWAS) and whole exome sequencing (WES) analyses. Methods: 530 participants from the Fluocinolone Acetonide in Diabetic Macular Edema (FAME) trials were analyzed, with replication performed in an independent cohort of 588 participants from the Mass Eye and Ear/Retina Health Center (MEE/RHC). All participants were exposed to GC, primarily via i...

Articles
Lama J, Liu R, Huerta-Chagoya A, Li A, Huynh K, Stanwyck LK, Han S, Zhao Y, Chan W, Chen L, Mukundan A, Meng D, Yang JY, Susarla G, Sang D, Papaliodis GN, Shen LQ, Rossin E, Elkins C, Benavides I, Wafapoor H, Cutino A, Wiggs JL, Eaton AM, Segrè AV, Sobrin L•
PubMed

Development and validation of an interpretable machine learning model to predict malignant cerebral edema after endovascular treatment in acute anterior circulation large vessel occlusion stroke.

Background Malignant cerebral edema (MCE) is a life-threatening complication following endovascular treatment (EVT) in patients with acute anterior circulation large vessel occlusion (LVO) stroke. This study aimed to develop and validate a machine learning (ML)-based predictive model for early risk assessment of MCE in this population. Methods We retrospectively collected data of 364 acute ischemic stroke patients with acute anterior circulation large vessel occlusion from a comprehensive str...

Articles
Dong Z, Huang Z, Hu H, Wang Y, Jiang C, Li G, Liu F, Zhu T, Shen H, Chen C, Zhang Y•
PubMed

Unveiling the role of extracellular vesicles in HIV infection: molecular mechanisms, viral persistence, and therapeutic opportunities.

Abstract Human immunodeficiency virus (HIV) infection remains a major global health challenge despite the success of antiretroviral therapy, largely due to the persistence of viral reservoirs and chronic immune dysregulation. Extracellular vesicles (EVs) have emerged as important mediators of intercellular communication during viral infection, operating at the interface between viral and host cellular pathways. Depending on their cellular origin and molecular cargo, EVs can exert context-depend...

Articles
Salzano F, Capuano N, Giordano F, De Bellis E, Conti V, Pagliano P, Franci G•
PubMed

Effects of Duration of Untreated Illness on Suicidal Ideation Among Patients With Panic Disorder.

Objective Patients with panic disorder (PD) are approximately four times more likely than the general population to exhibit suicidal ideation (SI) and suicide attempts. Although prolonged duration of untreated illness (DUI) is a known risk factor for adverse outcomes in mood disorders, its impact on suicidality among patients with PD has not been well established. This study investigated whether prolonged DUI is associated with heightened SI among patients with PD, considering sociodemographic...

Articles
Kim JE, Ham JY, Bae Y, Kim HJ, Lee SH•
PubMed

Peritoneal Sarcoidosis.

Patients presenting with weight loss and ascites of non‐portal etiology are frequently diagnosed with peritoneal carcinomatosis, a diagnosis that may be suggested by imaging modalities [1]. A 53‐year‐old woman presented to the surgical clinic with complaints of abdominal discomfort and distension over the past 6 months. She reported a 7 kg weight loss during this period. Physical examination revealed no stigmata of chronic liver disease, although moderate‐volume ascites was present. The patient...

Articles
Miranda LEC, de Sena AB, Vieira RB•
PubMed

Retinoic acid receptor β deletion in podocytes causes kidney and liver dysfunction, modeling nephrotic syndrome.

Differentially altered expression of transcripts of retinoic acid receptors α, β, γ (Rarα, β, γ), which mediate the actions of all-trans retinoic acid (RA), is observed in glomeruli of nephrotic syndrome (NS) patients vs normal individuals, with Rarβ reduced and both RARα and RARγ increased. Thus, we generated a mouse model (PCRB) with Rarβ specifically deleted in podocytes to define the glomerular actions of Rarβ. Rarβ deletion in PCRB mice results in podocyte loss, podocyte foot process efface...

Articles
Chi Y, DiKun KM, Tang XH, Warren CD, Chikara S, Mere Del Aguila E, Wagner JA, Geri JB, Gudas LJ•
PubMed

A neutralizing APOA5 monoclonal antibody reduces amounts of lipoprotein lipase in capillaries and triggers hypertriglyceridemia.

Apolipoprotein AV (APOA5) regulates intravascular triglyceride metabolism by binding to the angiopoietin-like protein 3/8 complex (ANGPTL3/8) and suppressing its ability to unfold the native conformation of lipoprotein lipase (LPL). LPL unfolding results in loss of catalytic activity and the detachment of LPL from the surface of cells. An APOA5 truncation mutation (identified in two patients with hypertriglyceridemia) had suggested that the last 35 amino acids of APOA5 are important for its func...

Articles
Yang Y, Beigneux AP, Lowe TL, Chen YQ, Xie K, Jung H, Tu Y, Yu RG, Scheithauer JL, Mehta S, Wu J, Alvarez L, Davidson WS, Birrane G, Remaley AT, Sviridov D, Ploug M, Zhen EY, Qian Y, Sloan JH, Siegel RW, Konrad RJ, Fong LG, Young SG•