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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 1,837–1,848 of 2,098 articles

PubMed

Gut Microbiota Mediates the Relationship Between Immune Cells and Familial Hypercholesterolemia: A Mendelian Randomization Study.

Introduction Although extensive studies have revealed the critical role of immune cells in the pathogenesis of Familial Hypercholesterolemia (FH), the interplay between immune cells and gut microbiota and their potential mediating effects in developing this disease still lacks systematic investigation. This study aimed to investigate the potential causal effects of immune cells on FH and evaluate the mediating role of gut microbiota in this process. Methods This study employed a two-sample Me...

Articles
Liang S, Zhou Z, Wang S, Xue Q, Wu A, Yang H, Sun Q•
PubMed

Juanbi Lijieqing Decoction Inhibits TLR4/NF-κB Signaling Pathway by Promoting PPARγ Expression to Relieve Acute Gouty Arthritis.

Introduction This study aimed to investigate the mechanism of Juanbi Lijieqing Decoction (JLD) in alleviating acute gouty arthritis (AGA) by modulating PPARγ expression to suppress the TLR4/NF-κB pathway. Methods A total of 84 male SD rats were divided into 7 groups of 12 rats. One group was randomly selected as the normal control group (Group A), while the remaining 72 rats were used to establish an acute gouty arthritis model through intraperitoneal injection of potassium oxonate combined w...

Articles
Lu C, Zhu F, Luo Z, Xiong H, Guo Y•
PubMed

MX2 and IRF7 are Associated With Disease Activity and Renal Involvement in Systemic Lupus Erythematosus: An Exploratory Study.

Background Systemic lupus erythematosus (SLE) has multiple phenotypes, one of which is lupus nephritis (LN), a very serious complication with a high mortality rate. Patients with LN may require different treatment regimens than patients with SLE, as there are significant differences between SLE and LN pathogenesis; however, to date, no biomarkers specific for LN have been characterized. Identification of immunological markers of LN could therefore facilitate more individualized treatment strate...

Articles
Zhang F, Huang Y, Liu H, Zhang Y, Li Z, Xie Z, Sun J•
PubMed

The Role of m6A Modification in the Development of Systemic Lupus Erythematosus via the TGF-β Signaling Pathway.

N6‐methyladenosine (m6A) modification is the most widespread RNA internal modification involved in RNA metabolism, participating in cell biology and immune responses. In the early stage of systemic lupus erythematosus (SLE), m6A modification can affect the production of autoantibodies by regulating the differentiation of T follicular helper (Tfh) cells and the generation of autoreactive B cells. With the development of SLE, its subsequent action in immune complexes (ICs)‐deposited tissues is the...

Articles
Xia X, Qu R•
PubMed

Uncovering Mediating Mechanisms Linking Immune Cells to Systemic Lupus Erythematosus: Insights into Mendelian Randomization.

Introduction Systemic lupus erythematosus (SLE) involves dysregulated immune cell function, though its exact pathogenic mechanisms remain unclear. Methods We performed a two-sample Mendelian randomization (MR) study using extensive GWAS summary statistics, covering 731 immune cell phenotypes, 91 inflammatory proteins, 179 lipid types, 1,400 blood metabolites, and SLE cases. The analysis aimed to evaluate causal associations between these variables and SLE. Additionally, we investigated possib...

Articles
Liu Z, Kuang L, Zhao J, Yin H, Liu X, Liu D, Wu S, Wu L•
PubMed

Factors Associated With Elevated C-Reactive Protein Levels in Women With Systemic Lupus Erythematosus Followed at the Cocody University Hospital, Abidjan, Côte d'Ivoire.

Systemic lupus erythematosus (SLE) is a chronic autoimmune connective tissue disease characterised by multivisceral involvement and the presence of autoantibodies. In this context, C‐reactive protein (CRP) holds a particular position: a moderate rise accompanies autoimmune flares, whereas a sharp elevation suggests an infection or specific inflammatory manifestations. This study aimed to analyse the factors associated with increased CRP levels in women with lupus followed at the Cocody Universit...

Articles
Adou AH, Coulibaly AK, Memel LCR, Siransy KL•
PubMed

Neurotized Free Anterolateral Thigh Flap for Large Tissue Defect and Joint Exposure in the Setting of Olecranon Bursitis: A Case Report.

Elbow wounds secondary to septic olecranon bursitis are a challenging problem to treat. Neurotized fasciocutaneous free anterolateral thigh (ALT) flaps provide a reliable soft tissue coverage option with the opportunity to provide protective sensation to a common pressure point. Free flaps can provide coverage when alternative options lower on the reconstructive ladder are unavailable. A 69-year-old man with rheumatoid arthritis presented with septic olecranon bursitis requiring serial debrideme...

Articles
Zeyl VG, Mahajan AY, Loewenstein SN•
PubMed

Prognostic utility of interim (18)F-FDG PET/CT after two cycles of ABVD in response assessment in Hodgkin's lymphoma patients: single-center preliminary experience.

Objective(s): This study evaluates the utility of interim 18F-FDG PET/CT (iPET)-guided therapy in a Southeast Asian population, addressing gaps in region-specific data. Key outcomes included treatment response rates and progression-free survival (PFS) stratified by iPET results (Deauville score (DS) 1-3 vs. 4-5) across all clinical risk groups (including early-stage favorable/unfavorable and advanced-stage based on the International Prognostic Score (IPS)). Findings will inform optimal risk-ada...

Articles
Toan NQ, Thai PV, Dung LT, Son MH, Son PL, Nga DH, Quang LV, Ha LN•
PubMed

Risk of Type II Diabetes Mellitus Among B-Cell Non-Hodgkin's Lymphoma Survivors.

ABSTRACT Purpose Advancing therapies have increased B‐cell Non‐Hodgkin's Lymphoma (B‐NHL) patient survival. However, data are limited on the risk of type II diabetes mellitus (type II DM) in adult survivors following treatment. This study examines the risk of type II DM among a Utah population of B‐NHL survivors, compared to the general population. Methods A cohort of 3529 adult survivors diagnosed with B‐NHL in Utah between 1997 and 2013 in the Utah Cancer Registry and 13,339 individuals fr...

Articles
Chi E, Chang DK, Chang CE, Kim S, Park J, Snyder J, Deshmukh V, Newman MG, Lee CJ, Hashibe M•
PubMed

Crohn's Disease Phenotype in a Patient With Severe Congenital Neutropenia Caused by CSF3R Variants: Exploring the Pathogenesis and Effects of Thalidomide Treatment.

This study describes a case of severe congenital neutropenia (SCN) harboring biallelic CSF3R variants and presenting with a novel inflammatory bowel disease (IBD) phenotype that responded remarkably to thalidomide. We performed functional studies to reveal the pathogenicity of the CSF3R and to elucidate the potential mechanisms underlying the therapeutic effects of thalidomide. A comprehensive review of the literature identified 18 reported cases of SCN associated with CSF3R variants. We subsequ...

Articles
Wang Y, Wang L, Pan C, Huang Z, Li P, Qiu X, Zheng C, Huang Y•
PubMed

CD27 and GZMK as Co-Biomarkers in Rheumatoid Arthritis and Crohn's Disease and Mediate Immune Imbalance.

Background Studies have found similar immune responses, genetic susceptibility, and inflammatory mediators between Rheumatoid arthritis (RA) and Crohn’s disease (CD), but these findings are controversial. Methods The Gene Expression Omnibus (GEO) was utilized to get microarray data. Differentially expressed genes (DEGs) in individuals with CD and RA were identified. Weighted gene co-expression network analysis (WGCNA) was used to identify key modular genes in CD and RA. The least absolute shr...

Articles
Zheng L, Zeng Y, Fang M, Heng H, Luo Y, Zhong J•
PubMed

Integrative eQTL and Mendelian Randomization Analyses with Experimental Validation Prioritize Genetic Candidate Biomarkers for Crohn's Disease.

Introduction Crohn's disease (CD) is a chronic, idiopathic inflammatory bowel disease. Understanding the genetic and immunological basis of CD can lead to better therapeutic strategies. Methods We employed publicly available datasets from the Gene Expression Omnibus (GEO) database to identify instrumental variables through expression quantitative trait loci (eQTL) analysis and conducted two-sample Mendelian randomization (MR) analyses. Additionally, we investigated the functions and pathways...

Articles
Zhang X, Liu L, Xu W, Li G, Qin Q, Zhang J•