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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 1,849–1,860 of 2,098 articles

PubMed

Association between Suicidal Ideation and Immune Parameters in First-episode Patients with Schizophrenia.

Introduction Disturbed immunity and inflammation have been associated with the pathogenesis of schizophrenia (SZ) and suicidal behaviors. We hypothesized that the neutrophil-to-lymphocyte ratio (NLR) was associated with the increased risk of suicide ideation (SI) in patients with SZ. Methods A total of 97 drug-naïve first-episode patients with SZ (15 with SI and 82 without SI) were recruited in the present study. The symptom severity was assessed using the Positive and Negative Syndrome Scale...

Articles
Xia Y, Guan X, Xiu M, Wu F•
PubMed

Lurasidone vs. Other Antipsychotics as Augmentation Strategies for Clozapine in Treatment-resistant Schizophrenia: An Observational Multicenter Prospective Study.

Introduction Clozapine, after its introduction, reshaped the landscape of Treatment-Resistant Schizophrenia (TRS) treatment, becoming the first-line treatment for that condition. However, many patients fail to respond to this drug alone. Clozapine-resistant schizophrenia (CRS) is associated with a more severe clinical presentation than TRS, manifesting in exacerbated symptoms and significantly diminished quality of life. The complex nature of CRS has prompted the development of augmentation str...

Articles
Prodi T, Benatti B, Grecchi A, Oresti M, Mazzoni F, Carnevale Miacca G, Brondino N, Dell'Osso B, Olivola M•
PubMed

Adverse Drug Reactions of Low and Standard Doses of Risperidone in Schizophrenia Outpatients.

Introduction Risperidone is an atypical antipsychotic commonly used in the treatment of schizophrenia. Despite its effectiveness, several adverse drug reactions can be bothersome to patients. This study aimed to examine the prevalence and characteristics of adverse effects in outpatients with schizophrenia treated with low (<4 mg/day) and standard (≥4 mg/day) doses of risperidone. Methods A cross-sectional study was conducted with 64 patients at a tertiary psychiatric hospital. Data on advers...

Articles
Boonlue T, Karnkla P, Jansela S, Werawattanachai C•
PubMed

Dissociable anterior and posterior beta-burst dynamics track thought disorder in schizophrenia.

Background Thought disorder in schizophrenia likely reflects disrupted maintenance of internal models during predictive processing. Beta oscillations have been proposed to index top-down predictive signalling, but prior resting-state studies have focused on spectral power, overlooking transient burst dynamics that potentially stabilize and reinstate internal representations, especially in the default mode network (DMN). Methods Resting-state magnetoencephalography was acquired from 25 patient...

Articles
Wei H, Power L, Dou R, Baillet S, Palaniyappan L•
PubMed

Shen-Ling-Bai-Zhu-San Mitigates Ulcerative Colitis by Enhancing Intestinal Barrier Integrity via the AhR-CYP1A1-NF-κB Signal Pathway.

Introduction Ulcerative Colitis (UC) represents a persistent inflammatory disorder of the colon, typically characterized by abdominal discomfort, diarrhea, and blood stools. Shen-Ling-Bai-Zhu-San (SLBZS), a traditional Chinese herbal formula, has shown clinical efficacy in alleviating symptoms such as abdominal bloating, frequent loose stools, and diarrhea. Nonetheless, the precise molecular mechanisms underlying its therapeutic effects remain largely unclear. Methods UPLC-QE-MS combined with...

Articles
Ming L, Chen J, Ma J, Guo S, Xu K, Ji J, Zhao Z, Xu S, Huang Q•
PubMed

Genome-wide Association Studies of the Pathogenic Sphingosine-1-Phosphate Gene in Ulcerative Colitis.

Background Ulcerative colitis (UC) is a chronic inflammatory bowel disease that can lead to malignancies over time. Sphingosine-1-phosphate (S1P) receptor signaling affects lymphocyte trafficking and vascular integrity, influencing intestinal inflammation. This study aimed to identify S1P-related key genes in UC. Methods Differentially expressed genes (DEGs) between the UC and control groups were analyzed in the GSE87473 (training) dataset. Genes overlapping between the DEGs and S1P-related g...

Articles
Chen H, Shang J, Zhao S, Xu L, Shen H•
PubMed

A Comprehensive Data Mining-Based Study for Review of Animal Studies on Traditional Chinese Medicine Prescriptions for Treating Ulcerative Colitis.

Background Ulcerative colitis (UC) is a complex disease associated with immune dysregulation. Classic prescriptions (CP) of traditional Chinese medicine have a strong theoretical foundation and a long history of clinical use in treating UC. This study aims to uncover the intrinsic patterns and characteristics of these CPs. Methods Data mining of CP literature for UC from VIP, CNKI, WanFang, and PubMed (2013–2023), which focused on herb usage frequency, properties, flavors, meridian tropisms,...

Articles
Wang J, Xu JH, Zhang MM, Li Y, Xiao HM, Li M•
PubMed

Clinical Response and Improvement of the Quality of Life, Fatigue, Mood, and Sleep Disturbances During Vedolizumab Induction Therapy in Polish Patients With Moderate-to-Severe Ulcerative Colitis or Crohn's Disease.

Background Inflammatory bowel disease (IBD) encompasses chronic gastrointestinal disorders that significantly impact patients’ quality of life (QoL). While clinical trials support the efficacy and safety of vedolizumab, real‐world data linking its effectiveness to QoL‐related patient‐reported outcomes remain limited. This prospective observational study assessed the effects of 14‐week vedolizumab induction therapy on QoL (i.e., fatigue, mood, and sleep disturbances), clinical response, safety,...

Articles
Michalak A, Zawada I, Deskur A, Kopertowska-Majchrzak M, Talar-Wojnarowska R, Domżał-Magrowska D, Eder P, Stawczyk-Eder K, Waszak K, Rydzewska-Wyszkowska G, Maciejewska K, Karłowicz K, Gąsiorowska A, Kaczka A, Konecki Ł, Krogulecki M, Filipiuk A, Kłopocka M, Liebert A, Hartleb M, Gawron-Kiszka M, Poniewierka E, Gromny I, Zagórowicz E, Filip R, Majewska E, Cichoż-Lach H•
PubMed

Noninvasive Biomarkers for Early Detection of Primary Sclerosing Cholangitis in Ulcerative Colitis.

Primary sclerosing cholangitis (PSC) is a progressive cholestatic liver disease strongly associated with ulcerative colitis (UC). Although uncommon, PSC‐associated ulcerative colitis (PSCUC) represents a distinct subtype of inflammatory bowel diseases characterized by a higher risk of colorectal and hepatobiliary cancers. Early diagnosis remains a challenging issue because of the lack of specific biomarkers. Bioinformatic analysis of Gene Expression Omnibus (GEO) datasets identified potential, s...

Articles
Asadi Sarabi P, Beheshti-Maal A, Judaki AA, Teymoorian SK, Hashemian Z, Rismani E, Gul A, Malekzadeh R, Hassan M, Vosough M•
PubMed

Fuzi-Baijiangcao Herb Pair Alleviates DSS-induced Ulcerative Colitis in Mice via Inhibiting the p38 MAPK/NF-κB/HIF-1α Signaling Pathway.

Background Ulcerative colitis is an inflammatory intestinal tract disease that is complex and difficult to heal, and prone to recurrence. The Fuzi-Baijiangcao (FB) herb pair is a commonly used drug combination for the clinical treatment of UC in China. However, its underlying mechanisms have not been elucidated. In this study, we explored the active ingredients of the FB herb pair and its potential mechanisms in the treatment of UC. Methods Firstly, the active ingredients and potential target...

Articles
Sun C, Jiang Y, Wang X•
PubMed

Clinical and Histopathological Characteristics of Granuloma Annulare: Significance of Giant Cells and Systemic Inflammatory Markers.

Background: Granuloma Annulare (GA) is a chronic inflammatory dermatosis with diverse presentations, yet comprehensive data integrating histopathology, long-term prognosis, and systemic inflammatory markers remain limited. This study aimed to analyze these clinicopathological characteristics and identify biomarkers for chronicity and recurrence. Methods: In this retrospective cohort study, we evaluated 34 patients with histopathologically confirmed GA diagnosed between 2013 and 2023. Demographic...

Articles
Hayat ZG, Civriz AH, Solak B•
PubMed

Frequency-Dependent Effects of Warm Needle Acupuncture in Patients With Knee Osteoarthritis With Cold-Dampness Obstruction Syndrome: A Randomized Controlled Trial.

Background Knee osteoarthritis (KOA) is a common chronic degenerative joint disease. Its rising incidence, driven by population aging and increasing obesity rates, imposes a growing socioeconomic burden. As a therapy integrating the dual merits of acupuncture regulation and thermal stimulation, warm acupuncture has been widely adopted for KOA, accompanied by a growing body of relevant research. However, standardized recommendations regarding optimal treatment frequency and course duration of wa...

Articles
Deng H, Su Q, Wang Y, Wang J, Liu K, Fu L, Li S, Xu S, Mi Y•