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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 1,861–1,872 of 2,098 articles

PubMed

The Gut-Joint Axis in Osteoarthritis: A Bibliometric Analysis of Research Trends and Mechanistic Insights (2008-2025).

Introduction Osteoarthritis (OA) is a leading cause of disability, and emerging evidence highlights the gut–joint axis as critical in its pathogenesis and therapy. To date, no bibliometric synthesis has comprehensively mapped this field. Methods We searched the Web of Science Core Collection (2008–2025) for original studies on gut microbiota and OA. Bibliometric and network analyses were performed using bibliometrix (R) and VOSviewer to assess publication trends, citations, collaborations, an...

Articles
Liu X, Zhang Y, Ye N•
PubMed

P2 Receptors as Therapeutic Targets in Allergic Rhinitis: Insights From the Use of Natural Products and Preclinical Studies.

Allergic rhinitis (AR) is a chronic inflammatory disorder of the upper airways that is mediated by immunoglobulin E (IgE) and triggered by environmental allergens. Current pharmacological therapies, including antihistamines, corticosteroids, and immunotherapy, offer symptomatic relief but are limited by their incomplete disease‐modulating effects and potential adverse side effects. Purinergic P2 receptors (P2Rs; P2X and P2Y subtypes) have emerged as key modulators of allergic inflammation and re...

Articles
Pereira TC, Rocha L, Faria RX•
PubMed

Integrated Molecular Docking and Dynamic Simulations Reveal Glycyrrhizic Acid Alleviates Allergic Rhinitis in Rats by Inhibiting the TLR4/NF-κB/IL-1β Pathway.

Background Allergic rhinitis (AR) is a prevalent chronic inflammatory nasal disorder with suboptimal current therapies. Glycyrrhizic acid (GA), a bioactive triterpenoid from Glycyrrhiza uralensis, exerts well‐documented antiinflammatory effects, and preliminary evidence indicates its efficacy in alleviating airway inflammation in AR models. However, two critical knowledge gaps remain unaddressed: whether GA directly binds to core proteins of the toll‐like receptor 4 (TLR4)/nuclear factor‐kappa...

Articles
Huang J, Ren X, Chen X, Zheng X•
PubMed

Development of a Mast-Cell Activation Test for Diagnosing Allergic Rhinitis.

Serum‐specific IgE (sIgE) and skin prick testing (SPT) have limitations in diagnosing allergic rhinitis (AR). CD63, a mast cell activation biomarker reflecting degranulation extent, has unclear application in AR diagnosis. This study developed a functional mast cell activation test (MAT) for the in vitro diagnosis of AR by quantifying CD63 expression on LAD2 cells stimulated with patient serum and specific allergens. The assay was evaluated in 128 AR patients and 115 controls. The assay showed g...

Articles
Pan J, Gong L, Xu J, Luo S, Wang C, Liu R, Zhang T, Zhang M•
PubMed

The Beneficial Effects of Combination Therapy With SGLT-2 Inhibitors and GLP-1 Receptor Agonists in Type 2 Diabetes Mellitus.

Type 2 diabetes mellitus is a chronic metabolic disorder associated with microvascular and macrovascular complications. Hyperglycemia and insulin resistance are core pathophysiological components of diabetes, linked to subclinical inflammation and persistent oxidative stress, which result in endothelial dysfunction and subsequent atherogenesis. Nowadays, several arrows in the diabetologist's quiver are available for the management of diabetes, providing flexibility and the ability to adopt a per...

Articles
Kalogeris A, Ikonomidis I, Kyriakoulis KG, Pavlidis G, Thymis J, Katogiannis K, Kountouri A, Pliouta L, Pililis S, Korakas E, Lambadiari V•
PubMed

COVID-19 Impact on Lipid Profile and Metabolome in Patients with Type 2 Diabetes Mellitus: Mini-Review.

Aim This review aims to explore the pathophysiological mechanisms by which SARS-CoV-2 affects lipid metabolism and the metabolome in patients with Type 2 Diabetes Mellitus (T2DM). It compares these alterations with those observed in non-diabetic individuals and proposes strategies to mitigate potential long-term metabolic complications. Methods A narrative review was conducted using PubMed, Scopus, and Google Scholar to identify studies published between 2004 and 2025 concerning adult T2DM pa...

Articles
Pawłuszkiewicz K, Augustynowicz G, Paluch E, Porebska B, Bielenin Z, Faltus AM, Madziarska K, Kluz J, Bronowicka-Szydelko A•
PubMed

Chain Mediating Role of Illness Perception and Fear of Hypoglycemia in Impaired Hypoglycemic Awareness and Mild Cognitive Impairment in Patients with Type 2 Diabetes Mellitus.

Introduction Impaired hypoglycemic awareness (IAH) in type 2 diabetes mellitus (T2DM) is linked to mild cognitive impairment (MCI), but the underlying mechanisms are unclear. This study aimed to explore the chain mediating role of two psychological factors, illness perception (IP) and fear of hypoglycemia (FOH), in the relationship between IAH and MCI. Methods A cross-sectional survey of 251 T2DM patients was conducted using convenience sampling at two tertiary hospitals. Data on IAH, IP, FOH...

Articles
Han M, Li X, He Y, Kan Y, Wan X, Liu L, Su Y, Chen J, Fang L, Wang J, Zhang Y•
PubMed

Major depressive disorder is associated with reduced intrinsic connectivity between the bed nucleus of the stria terminalis and ventral striatum.

Background: The bed nucleus of the stria terminalis (BNST) plays a critical role in the neural processing of negative emotions. To date, no studies have investigated whether intrinsic connectivity of the BNST is associated with major depressive disorder (MDD) or with the severity of clinical symptoms in individuals with depression. Methods: Resting-state functional magnetic resonance imaging (7 Tesla (7T)) with seed-to-voxel-analysis was used to compare the intrinsic connectivity of the BNST...

Articles
Gorka A, Evans J, Kvarta M, Ballard E, Zarate C•
PubMed

Quality of Service and Cost of Managing an Episode of Major Depressive Disorder: A Cohort Study in Iran.

Background: Major depressive disorder (MDD), a major cause of the burden of diseases, is associated with a considerable rate of inadequate treatment and high costs. We assessed the pattern of service use, quality, and costs of healthcare for MDD in Iran. Methods: We assessed a national sample of 265 patients in the acute phase of MDD recruited from outpatient/inpatient settings at baseline and in three follow-up points of one, three, and six months. The pattern of service use and selected qua...

Articles
Amin-Esmaeili M, Baheshmat S, Rahimi-Movaghar A, Samimi Ardestani SM, Samadi R, Hajebi A, Farzy Y, Moghimi-Sarani E, Khatibzadeh S, Shahraz S•
PubMed

Mendelian Randomization Studies of Major Depressive Disorder, Schizophrenia, Bipolar Disorder, and Cancers: A PRISMA Review and Meta-Analysis.

Introduction Previous literature has reported ambiguous results regarding the association of severe psychiatric disorders and an increasing risk of cancer disease. The aim of our analysis was to explore any associations between severe psychiatric disorder (SPD), like schizophrenia (SCZ), Bipolar Disorder (BD) and recurrent major depression (MDD), and cancer diseases by meta-analyzing Mendelian Randomization (MR) studies available in the current literature. Methods The present systematic revie...

Articles
Vitale E, Maistrello L, Rizzo A, Santoni M, Motamed-Jahromi M, Sallustio A, Tramacere F•
PubMed

Tempol Ameliorates Psoriatic Skin Inflammation: Evidence of TLR4/NF-κB/Nrf2 Axis Modulation.

Psoriasis is a chronic inflammatory skin disorder characterized by keratinocyte hyperproliferation, immune dysregulation, oxidative stress, and impaired epidermal barrier function. In the present study, we investigated the protective effects of Tempol, a membrane‐permeable nitroxide with antioxidant and anti‐inflammatory properties, using several psoriasiform models. In HaCaT keratinocytes, stimulation with a cytokine mixture significantly induced inflammatory responses. Tempol (0.5 and 1 mM) sh...

Articles
Scuderi SA, Lanza M, Capra AP, Catalfamo A, Esposito E, Ardizzone A•
PubMed

STAT3 ablation in keratinocytes ameliorates allergic contact dermatitis in DNCB-induced mice model.

Objective(s): Allergic contact dermatitis (ACD) is a T cell-mediated type IV hypersensitivity reaction to haptens. Its pathogenesis involves keratinocyte dysfunction and dysregulation of the Signal Transducer and Activator of Transcription 3 (STAT3)-signaling pathway. However, the specific role of keratinocyte produced STAT3 in ACD remains unclear. To investigate the effect of keratinocyte (KC)-specific STAT3 conditional knockout on 1-Chloro-2,4-dinitrobenzene (DNCB)-induced ACD in mice. Mater...

Articles
Chen L, Zhang C, Li L, Wang H, Yao W, Xing L, Gao J, Li Z, Tian F•