Antidepressant Serotonin-2 Antagonist Reuptake Inhibitors

Antidepressant serotonin-2 antagonist and reuptake inhibitors, commonly referred to as SARIs, are a distinct class of psychotropic medications that include agents such as trazodone and nefazodone Clinically, this class is indicated for the treatment of major depressive disorder and related depressive conditions Owing to marked sedative properties and concurrent alpha-adrenergic and histaminergic activity, specific agents in this class are also widely utilized in clinical practice to manage comor...

Antidepressant serotonin-2 antagonist and reuptake inhibitors, commonly referred to as SARIs, are a distinct class of psychotropic medications that include agents such as trazodone and nefazodone Clinically, this class is indicated for the treatment of major depressive disorder and related depressive conditions

These agents exert their therapeutic effect primarily by antagonizing postsynaptic serotonin 5-HT2A receptors while concurrently inhibiting the presynaptic reuptake of serotonin, thereby modulating central serotonergic neurotransmission and reducing certain adverse effects linked to non-selective receptor stimulation

Owing to marked sedative properties and concurrent alpha-adrenergic and histaminergic activity, specific agents in this class are also widely utilized in clinical practice to manage comorbid insomnia and anxiety