Drug class

Antidepressant Serotonin-2 Antagonist Reuptake Inhibitors

Antidepressant serotonin-2 antagonist and reuptake inhibitors, commonly referred to as SARIs, are a distinct class of psychotropic medications that include agents such as trazodone and nefazodone. Read more about Antidepressant Serotonin-2 Antagonist Reuptake Inhibitors

29 drugs in this class 28 manufacturers

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Drugs in Antidepressant Serotonin-2 Antagonist Reuptake Inhibitors

Showing 28–29 of 29 drugs

TRAZODONE HCL

ANTIDEPRESSANTS · MAJOR DEPRESSIVE DISORDER
TRUPHARMA, LLC.

TRAZODONE HCL

ANTIDEPRESSANTS · MAJOR DEPRESSIVE DISORDER
OXFORD PHARMACE
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About Antidepressant Serotonin-2 Antagonist Reuptake Inhibitors.

Antidepressant serotonin-2 antagonist and reuptake inhibitors, commonly referred to as SARIs, are a distinct class of psychotropic medications that include agents such as trazodone and nefazodone.

These agents exert their therapeutic effect primarily by antagonizing postsynaptic serotonin 5-HT2A receptors while concurrently inhibiting the presynaptic reuptake of serotonin, thereby modulating central serotonergic neurotransmission and reducing certain adverse effects linked to non-selective receptor stimulation.

Clinically, this class is indicated for the treatment of major depressive disorder and related depressive conditions.

Owing to marked sedative properties and concurrent alpha-adrenergic and histaminergic activity, specific agents in this class are also widely utilized in clinical practice to manage comorbid insomnia and anxiety.