Drug class

GI Stimulants

Gastrointestinal stimulants, widely referred to in clinical practice as prokinetic agents, are a therapeutic drug class that enhances gastrointestinal smooth muscle motility and accelerates luminal transit without functioning primarily as purgative laxatives. Read more about GI Stimulants

40 drugs in this class 38 manufacturers

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Drugs in GI Stimulants

Showing 1–9 of 40 drugs

METOCLOPRAMIDE HCL

ANTIEMETIC · GASTROINTESTINAL RADIOGRAPHY ADJUNCT ·+4
Teva Parenteral Medicines

METOCLOPRAMIDE HCL

ANTIEMETIC · GASTROINTESTINAL RADIOGRAPHY ADJUNCT ·+4
NOVAPLUS/TEVA
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About GI Stimulants.

Gastrointestinal stimulants, widely referred to in clinical practice as prokinetic agents, are a therapeutic drug class that enhances gastrointestinal smooth muscle motility and accelerates luminal transit without functioning primarily as purgative laxatives.

These medications typically act by modulating enteric neurotransmission—most commonly through dopamine-2 receptor antagonism, serotonin receptor modulation (such as 5-HT4 receptor agonism), or direct cholinergic stimulation—to augment coordinated contractions, increase lower esophageal sphincter tone, and accelerate gastric emptying.

Clinically, GI stimulants are predominantly indicated for motility-related upper gastrointestinal conditions, including diabetic and idiopathic gastroparesis, refractory gastroesophageal reflux disease (GERD), and select functional dyspepsia syndromes.