Drug class

Immunosuppressants - Calcineurin Inhibitors

Immunosuppressants in the calcineurin inhibitor class are targeted pharmacologic agents that dampen T-cell–mediated immune responses. Read more about Immunosuppressants - Calcineurin Inhibitors

49 drugs in this class 37 manufacturers

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Drugs in Immunosuppressants - Calcineurin Inhibitors

Showing 19–27 of 49 drugs

TACROLIMUS

IMMUNOSUPPRESSANTS - CALCINEURIN INHIBITORS · PREVENTION OF KIDNEY TRANSPLANT REJECTION ·+3
STRIDES PHARMA

PROGRAF (tacrolimus)

IMMUNOSUPPRESSANTS - CALCINEURIN INHIBITORS · PREVENTION OF KIDNEY TRANSPLANT REJECTION ·+3
Astellas Pharma US

CYCLOSPORINE

ANTIPSORIATICS · PREVENTION OF KIDNEY TRANSPLANT REJECTION ·+2
American Regent

TACROLIMUS

IMMUNOSUPPRESSANTS - CALCINEURIN INHIBITORS · PREVENTION OF KIDNEY TRANSPLANT REJECTION ·+3
NORTHSTAR RX LL

TACROLIMUS

IMMUNOSUPPRESSANTS - CALCINEURIN INHIBITORS · PREVENTION OF KIDNEY TRANSPLANT REJECTION ·+3
APHENA PHARMA S

TACROLIMUS

IMMUNOSUPPRESSANTS - CALCINEURIN INHIBITORS · PREVENTION OF KIDNEY TRANSPLANT REJECTION ·+3
BPI LABS, LLC

TACROLIMUS

IMMUNOSUPPRESSANTS - CALCINEURIN INHIBITORS · PREVENTION OF KIDNEY TRANSPLANT REJECTION ·+3
A-S MEDICATION

TACROLIMUS

IMMUNOSUPPRESSANTS - CALCINEURIN INHIBITORS · PREVENTION OF KIDNEY TRANSPLANT REJECTION ·+3
GSMS, INC.
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About Immunosuppressants - Calcineurin Inhibitors.

Immunosuppressants in the calcineurin inhibitor class are targeted pharmacologic agents that dampen T-cell–mediated immune responses.

They exert their therapeutic effect by binding to intracellular immunophilins, such as cyclophilin or FK-binding proteins, thereby inhibiting the phosphatase enzyme calcineurin and blocking the transcription of interleukin-2 and other essential proinflammatory cytokines.

Clinically, these agents—most notably cyclosporine, tacrolimus, and voclosporin—serve as a cornerstone in preventing and managing organ allograft rejection following solid organ transplantation.

They are also widely utilized in rheumatology, nephrology, and dermatology to treat diverse immune-mediated and inflammatory conditions, including lupus nephritis, rheumatoid arthritis, and atopic dermatitis.