Drug class
Immunosuppressants - Calcineurin Inhibitors
Immunosuppressants in the calcineurin inhibitor class are targeted pharmacologic agents that dampen T-cell–mediated immune responses. Read more about Immunosuppressants - Calcineurin Inhibitors
49 drugs in this class 37 manufacturers
Drugs in Immunosuppressants - Calcineurin Inhibitors
CYCLOSPORINE MODIFIED (cyclosporine, modified)
CYCLOSPORINE MODIFIED (cyclosporine, modified)
TACROLIMUS
TACROLIMUS
TACROLIMUS
NEORAL (cyclosporine, modified)
SANDIMMUNE (cyclosporine)
TACROLIMUS XL (tacrolimus)
Immunosuppressants in the calcineurin inhibitor class are targeted pharmacologic agents that dampen T-cell–mediated immune responses.
They exert their therapeutic effect by binding to intracellular immunophilins, such as cyclophilin or FK-binding proteins, thereby inhibiting the phosphatase enzyme calcineurin and blocking the transcription of interleukin-2 and other essential proinflammatory cytokines.
Clinically, these agents—most notably cyclosporine, tacrolimus, and voclosporin—serve as a cornerstone in preventing and managing organ allograft rejection following solid organ transplantation.
They are also widely utilized in rheumatology, nephrology, and dermatology to treat diverse immune-mediated and inflammatory conditions, including lupus nephritis, rheumatoid arthritis, and atopic dermatitis.
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nih.gov
Immunosuppressants in the calcineurin inhibitor class are targeted pharmacologic agents that dampen T-cell–mediated immune responses They exert their therapeutic effect by binding to intracellular immunophilins, such as cyclophilin or FK-binding proteins, thereby inhibiting the phosphatase enzyme calcineurin and blocking the transcription of interleukin-2 and other essential proinflammatory cytokines Clinically, these agents—most notably cyclosporine, tacrolimus, and voclosporin—serve as a corne...
-
nih.gov
Immunosuppressants in the calcineurin inhibitor class are targeted pharmacologic agents that dampen T-cell–mediated immune responses
-
nih.gov
They exert their therapeutic effect by binding to intracellular immunophilins, such as cyclophilin or FK-binding proteins, thereby inhibiting the phosphatase enzyme calcineurin and blocking the transcription of interleukin-2 and other essential proinflammatory cytokines
-
fda.gov
Clinically, these agents—most notably cyclosporine, tacrolimus, and voclosporin—serve as a cornerstone in preventing and managing organ allograft rejection following solid organ transplantation
-
nih.gov
Clinically, these agents—most notably cyclosporine, tacrolimus, and voclosporin—serve as a cornerstone in preventing and managing organ allograft rejection following solid organ transplantation
-
nih.gov
They are also widely utilized in rheumatology, nephrology, and dermatology to treat diverse immune-mediated and inflammatory conditions, including lupus nephritis, rheumatoid arthritis, and atopic dermatitis
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