Drug class

Intrarectal Steroids

Intrarectal steroids are a route-specific therapeutic class of topical corticosteroid medications—including formulations such as rectal foams, enemas, and suppositories of agents like hydrocortisone or budesonide—designed for targeted administration into the lower gastrointestinal tract. Read more about Intrarectal Steroids

13 drugs in this class 9 manufacturers

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Drugs in Intrarectal Steroids

Showing 10–13 of 13 drugs

BUDESONIDE

GLUCOCORTICOSTEROIDS · ULCERATIVE COLITIS
Padagis US

HYDROCORTISONE

GLUCOCORTICOSTEROIDS · ULCERATIVE COLITIS
Avet Pharmaceuticals
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About Intrarectal Steroids.

Intrarectal steroids are a route-specific therapeutic class of topical corticosteroid medications—including formulations such as rectal foams, enemas, and suppositories of agents like hydrocortisone or budesonide—designed for targeted administration into the lower gastrointestinal tract.

They function by activating intracellular glucocorticoid receptors, thereby suppressing local cytokine synthesis, cellular extravasation, and mucosal inflammation while substantially minimizing the systemic adverse effects seen with oral or parenteral corticosteroids.

Clinically, these agents are primarily indicated for inducing remission and controlling acute disease flares in distal inflammatory bowel diseases, notably ulcerative proctitis and left-sided ulcerative colitis.