Drug class

Phosphonic Acid, Antibacterials

Phosphonic acid antibacterials are a distinct structural class of bactericidal antibiotics characterized by a carbon-to-phosphorus bond, with fosfomycin serving as the primary clinically utilized representative. Read more about Phosphonic Acid, Antibacterials

11 drugs in this class 11 manufacturers

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Drugs in Phosphonic Acid, Antibacterials

Showing 1–9 of 11 drugs

FOSFOMYCIN TROMETHAMINE

URINARY TRACT ANTI-INFECTIVES · ENTEROCOCCUS URINARY TRACT INFECTION ·+2
A-S MEDICATION

FOSFOMYCIN TROMETHAMINE

URINARY TRACT ANTI-INFECTIVES · ENTEROCOCCUS URINARY TRACT INFECTION ·+2
ASCEND LABORATO

FOSFOMYCIN TROMETHAMINE

URINARY TRACT ANTI-INFECTIVES · ENTEROCOCCUS URINARY TRACT INFECTION ·+2
CIPLA USA, INC.

FOSFOMYCIN TROMETHAMINE

URINARY TRACT ANTI-INFECTIVES · ENTEROCOCCUS URINARY TRACT INFECTION ·+2
Amneal Pharmaceuticals

FOSFOMYCIN TROMETHAMINE

URINARY TRACT ANTI-INFECTIVES · ENTEROCOCCUS URINARY TRACT INFECTION ·+2
AUROBINDO PHARM

FOSFOMYCIN TROMETHAMINE

URINARY TRACT ANTI-INFECTIVES · ENTEROCOCCUS URINARY TRACT INFECTION ·+2
AUCTA PHARMACEU
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About Phosphonic Acid, Antibacterials.

Phosphonic acid antibacterials are a distinct structural class of bactericidal antibiotics characterized by a carbon-to-phosphorus bond, with fosfomycin serving as the primary clinically utilized representative.

Agents in this class exert their antibacterial activity by inactivating UDP-N-acetylglucosamine enolpyruvyl transferase (MurA), irreversibly inhibiting the initial cytoplasmic step of bacterial peptidoglycan cell wall synthesis.

Because their mechanism precedes that of beta-lactams and glycopeptides, they lack cross-resistance with other major antimicrobial classes.

Clinically, they are predominantly utilized to treat uncomplicated urinary tract infections such as acute cystitis, as well as multidrug-resistant Gram-negative and Gram-positive bacterial infections, often as part of targeted combination regimens for complicated or systemic disease.