Drug class
Phosphonic Acid, Antibacterials
Phosphonic acid antibacterials are a distinct structural class of bactericidal antibiotics characterized by a carbon-to-phosphorus bond, with fosfomycin serving as the primary clinically utilized representative. Read more about Phosphonic Acid, Antibacterials
11 drugs in this class 11 manufacturers
Drugs in Phosphonic Acid, Antibacterials
FOSFOMYCIN TROMETHAMINE
Phosphonic acid antibacterials are a distinct structural class of bactericidal antibiotics characterized by a carbon-to-phosphorus bond, with fosfomycin serving as the primary clinically utilized representative.
Agents in this class exert their antibacterial activity by inactivating UDP-N-acetylglucosamine enolpyruvyl transferase (MurA), irreversibly inhibiting the initial cytoplasmic step of bacterial peptidoglycan cell wall synthesis.
Because their mechanism precedes that of beta-lactams and glycopeptides, they lack cross-resistance with other major antimicrobial classes.
Clinically, they are predominantly utilized to treat uncomplicated urinary tract infections such as acute cystitis, as well as multidrug-resistant Gram-negative and Gram-positive bacterial infections, often as part of targeted combination regimens for complicated or systemic disease.
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icb.nhs.uk
Phosphonic acid antibacterials are a distinct structural class of bactericidal antibiotics characterized by a carbon-to-phosphorus bond, with fosfomycin serving as the primary clinically utilized representative Clinically, they are predominantly utilized to treat uncomplicated urinary tract infections such as acute cystitis, as well as multidrug-resistant Gram-negative and Gram-positive bacterial infections, often as part of targeted combination regimens for complicated or systemic disease
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nih.gov
Phosphonic acid antibacterials are a distinct structural class of bactericidal antibiotics characterized by a carbon-to-phosphorus bond, with fosfomycin serving as the primary clinically utilized representative
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alodokter.com
Clinically, they are predominantly utilized to treat uncomplicated urinary tract infections such as acute cystitis, as well as multidrug-resistant Gram-negative and Gram-positive bacterial infections, often as part of targeted combination regimens for complicated or systemic disease
-
nih.gov
Clinically, they are predominantly utilized to treat uncomplicated urinary tract infections such as acute cystitis, as well as multidrug-resistant Gram-negative and Gram-positive bacterial infections, often as part of targeted combination regimens for complicated or systemic disease
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