Proton Pump Inhibitors

Proton pump inhibitors are a therapeutic class of antisecretory medications that produce potent and prolonged suppression of gastric acid production They function by covalently binding to and irreversibly inhibiting the gastric hydrogen-potassium ATPase enzyme system, commonly referred to as the proton pump, on the secretory surface of stomach parietal cells to block the final step of acid secretion

Proton pump inhibitors are a therapeutic class of antisecretory medications that produce potent and prolonged suppression of gastric acid production They function by covalently binding to and irreversibly inhibiting the gastric hydrogen-potassium ATPase enzyme system, commonly referred to as the proton pump, on the secretory surface of stomach parietal cells to block the final step of acid secretion

Agents in this class are widely indicated for acid-related gastrointestinal conditions, including gastroesophageal reflux disease, erosive esophagitis, gastric and duodenal peptic ulcer disease, Helicobacter pylori eradication regimens, and pathological hypersecretory states such as Zollinger-Ellison syndrome

Agents in this class are widely indicated for acid-related gastrointestinal conditions, including gastroesophageal reflux disease, erosive esophagitis, gastric and duodenal peptic ulcer disease, Helicobacter pylori eradication regimens, and pathological hypersecretory states such as Zollinger-Ellison syndrome