Rectal Steroids

Rectal steroids, also known as rectal corticosteroids, are a route-specific therapeutic class of synthetic glucocorticoids formulated as suppositories, foams, or retention enemas for localized administration to the lower gastrointestinal tract These agents exert potent local anti-inflammatory and immunosuppressive effects by diffusing into target cells, binding to cytoplasmic glucocorticoid receptors, and inhibiting the transcription of inflammatory cytokines and mediators in the colorectal muco...

Rectal steroids, also known as rectal corticosteroids, are a route-specific therapeutic class of synthetic glucocorticoids formulated as suppositories, foams, or retention enemas for localized administration to the lower gastrointestinal tract Clinically, they are primarily indicated for inducing remission in mild-to-moderate distal ulcerative colitis, ulcerative proctitis, and proctosigmoiditis, as well as managing radiation proctitis and inflammatory anorectal disorders

Rectal steroids, also known as rectal corticosteroids, are a route-specific therapeutic class of synthetic glucocorticoids formulated as suppositories, foams, or retention enemas for localized administration to the lower gastrointestinal tract

These agents exert potent local anti-inflammatory and immunosuppressive effects by diffusing into target cells, binding to cytoplasmic glucocorticoid receptors, and inhibiting the transcription of inflammatory cytokines and mediators in the colorectal mucosa, all while minimizing systemic bioavailability and side effects

These agents exert potent local anti-inflammatory and immunosuppressive effects by diffusing into target cells, binding to cytoplasmic glucocorticoid receptors, and inhibiting the transcription of inflammatory cytokines and mediators in the colorectal mucosa, all while minimizing systemic bioavailability and side effects

Clinically, they are primarily indicated for inducing remission in mild-to-moderate distal ulcerative colitis, ulcerative proctitis, and proctosigmoiditis, as well as managing radiation proctitis and inflammatory anorectal disorders

Clinically, they are primarily indicated for inducing remission in mild-to-moderate distal ulcerative colitis, ulcerative proctitis, and proctosigmoiditis, as well as managing radiation proctitis and inflammatory anorectal disorders