Pyoderma gangrenosum

Pyoderma gangrenosum is a rare, non-infectious inflammatory cutaneous disorder classified within the spectrum of neutrophilic dermatoses

Pyoderma gangrenosum is a rare, non-infectious inflammatory cutaneous disorder classified within the spectrum of neutrophilic dermatoses

It primarily affects adults—most commonly in their 30s to 50s—and frequently occurs alongside systemic autoimmune conditions such as inflammatory bowel disease, rheumatoid arthritis, or hematologic malignancies

It primarily affects adults—most commonly in their 30s to 50s—and frequently occurs alongside systemic autoimmune conditions such as inflammatory bowel disease, rheumatoid arthritis, or hematologic malignancies

Pathophysiologically driven by immune dysregulation, neutrophil dysfunction, and aberrant cytokine signaling, the condition is clinically characterized by painful, rapidly progressing skin pustules or nodules that break down into destructive ulcers with classic violaceous, undermined borders

Pathophysiologically driven by immune dysregulation, neutrophil dysfunction, and aberrant cytokine signaling, the condition is clinically characterized by painful, rapidly progressing skin pustules or nodules that break down into destructive ulcers with classic violaceous, undermined borders

Pathophysiologically driven by immune dysregulation, neutrophil dysfunction, and aberrant cytokine signaling, the condition is clinically characterized by painful, rapidly progressing skin pustules or nodules that break down into destructive ulcers with classic violaceous, undermined borders