Indication
Systemic mastocytosis
Systemic mastocytosis is a rare clonal hematologic neoplasm characterized by the abnormal proliferation and accumulation of genetically altered mast cells within extracutaneous tissues, most commonly the bone marrow, liver, spleen, gastrointestinal tract, and lymph nodes. Read more about Systemic mastocytosis
10 drugs 9 manufacturers
Drugs that treat it
Common Systemic mastocytosis therapies.
CROMOLYN SODIUM
CROMOLYN SODIUM
CROMOLYN SODIUM
CROMOLYN SODIUM
CROMOLYN SODIUM
GASTROCROM (cromolyn sodium)
CROMOLYN SODIUM
GASTROCROM (cromolyn sodium)
News & literature
Coming soonRelated codes
Coming soonRelated conditions & guidelines
Coming soonSystemic mastocytosis is a rare clonal hematologic neoplasm characterized by the abnormal proliferation and accumulation of genetically altered mast cells within extracutaneous tissues, most commonly the bone marrow, liver, spleen, gastrointestinal tract, and lymph nodes.
It predominantly affects adults and is driven in most patients by activating somatic mutations in the *KIT* receptor tyrosine kinase gene, such as KIT D816V.
Clinical manifestations range from indolent to aggressive disease, driven both by mast cell mediator release—causing episodic flushing, pruritus, abdominal pain, hypotension, and anaphylaxis—and by tissue infiltration that can lead to cytopenias, organomegaly, and end-organ dysfunction.
- cancer.gov
Systemic mastocytosis is a rare clonal hematologic neoplasm characterized by the abnormal proliferation and accumulation of genetically altered mast cells within extracutaneous tissues, most commonly the bone marrow, liver, spleen, gastrointestinal tract, and lymph nodes Clinical manifestations range from indolent to aggressive disease, driven both by mast cell mediator release—causing episodic flushing, pruritus, abdominal pain, hypotension, and anaphylaxis—and by tissue infiltration that can l...
- medlineplus.gov
Systemic mastocytosis is a rare clonal hematologic neoplasm characterized by the abnormal proliferation and accumulation of genetically altered mast cells within extracutaneous tissues, most commonly the bone marrow, liver, spleen, gastrointestinal tract, and lymph nodes It predominantly affects adults and is driven in most patients by activating somatic mutations in the *KIT* receptor tyrosine kinase gene, such as KIT D816V
- nih.gov
Systemic mastocytosis is a rare clonal hematologic neoplasm characterized by the abnormal proliferation and accumulation of genetically altered mast cells within extracutaneous tissues, most commonly the bone marrow, liver, spleen, gastrointestinal tract, and lymph nodes
- mayoclinic.org
It predominantly affects adults and is driven in most patients by activating somatic mutations in the *KIT* receptor tyrosine kinase gene, such as KIT D816V Clinical manifestations range from indolent to aggressive disease, driven both by mast cell mediator release—causing episodic flushing, pruritus, abdominal pain, hypotension, and anaphylaxis—and by tissue infiltration that can lead to cytopenias, organomegaly, and end-organ dysfunction
- medlineplus.gov
Clinical manifestations range from indolent to aggressive disease, driven both by mast cell mediator release—causing episodic flushing, pruritus, abdominal pain, hypotension, and anaphylaxis—and by tissue infiltration that can lead to cytopenias, organomegaly, and end-organ dysfunction
- bioontology.org
Clinical manifestations range from indolent to aggressive disease, driven both by mast cell mediator release—causing episodic flushing, pruritus, abdominal pain, hypotension, and anaphylaxis—and by tissue infiltration that can lead to cytopenias, organomegaly, and end-organ dysfunction
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