Unresectable or metastatic Kit (CD117) positive gastrointestinal stromal tumor

An unresectable or metastatic Kit (CD117) positive gastrointestinal stromal tumor is an advanced mesenchymal malignancy of the digestive tract arising from the interstitial cells of Cajal or their precursors Pathophysiologically, the tumor is characterized by strong immunohistochemical expression of the CD117 cell-surface marker, which corresponds to the KIT receptor tyrosine kinase and is predominantly driven by activating mutations that stimulate unchecked cellular proliferation In this clinic...

An unresectable or metastatic Kit (CD117) positive gastrointestinal stromal tumor is an advanced mesenchymal malignancy of the digestive tract arising from the interstitial cells of Cajal or their precursors Pathophysiologically, the tumor is characterized by strong immunohistochemical expression of the CD117 cell-surface marker, which corresponds to the KIT receptor tyrosine kinase and is predominantly driven by activating mutations that stimulate unchecked cellular proliferation

An unresectable or metastatic Kit (CD117) positive gastrointestinal stromal tumor is an advanced mesenchymal malignancy of the digestive tract arising from the interstitial cells of Cajal or their precursors In this clinical state, the neoplasm has either grown to involve critical structures making complete surgical removal impossible (unresectable) or has disseminated to distant sites, most commonly the liver and peritoneum (metastatic)

Pathophysiologically, the tumor is characterized by strong immunohistochemical expression of the CD117 cell-surface marker, which corresponds to the KIT receptor tyrosine kinase and is predominantly driven by activating mutations that stimulate unchecked cellular proliferation Affected adult populations often present with abdominal masses, gastrointestinal bleeding, obstruction, or systemic symptoms associated with advanced abdominal malignancy

In this clinical state, the neoplasm has either grown to involve critical structures making complete surgical removal impossible (unresectable) or has disseminated to distant sites, most commonly the liver and peritoneum (metastatic)